專家諮詢

姓名:
張維倫

學歷:
國立成功大學臨床醫學研究所博士(2007/09~)
國立成功大學臨床醫學研究所碩士(2006/09~2007/08)
國立陽明大學醫學系醫學士(1993/10~2000/06)

現任:
國立成功大學醫學院附設醫院胃腸肝膽科主治醫師

經歷:
國立成功大學醫學院內科學系臨床助理教授 (2011~)
國立成功大學醫學院附設醫院胃腸肝膽科主治醫師(2005/08~)
國立成功大學醫學院附設醫院胃腸肝膽科研究員
國立成功大學醫學院附設醫院內科住院醫師

專長:
●幽門桿菌
●胃食道逆流
●消化道癌症

著作:
1. Sheu, B. S., Chang, W. L., Cheng, H. C., Kao, A. W., & Lu, C. C. Body mass index can determine the healing of reflux esophagitis with Los Angeles Grades C and D by esomeprazole. Am J Gastroenterol 103, 2209-2214, 2008
2. Cheng, H. C., Chang, W. L., Chen, W. Y., Kao, A. W., Chuang, C. H., & Sheu, B. S. Long-term outcome of pyogenic liver abscess: factors related with abscess recurrence. J Clin Gastroenterol 42, 1110-1115, 2008
3. Chuang, C. H., Sheu, B. S., Yang, H. B., Lee, S. C., Kao, A. W., Cheng, H. C., Chang, W. L., & Yao, W. J. Gender difference of circulating ghrelin and leptin concentrations in chronic Helicobacter pylori infection. Helicobacter 14, 54-60, 2009
4. Yang, H. B., Sheu, B. S., Wang, S. T., Cheng, H. C., Chang, W. L., & Chen, W. Y. H. pylori eradication prevents the progression of gastric intestinal metaplasia in reflux esophagitis patients using long-term esomeprazole. Am J Gastroenterol 104, 1642-1649, 2009
5. Hung, K. H., Sheu, B. S., Chang, W. L., Wu, H. M., Liu, C. C., & Wu, J. J. Prevalence of primary fluoroquinolone resistance among clinical isolates of Helicobacter pylori at a University Hospital in Southern Taiwan. Helicobacter 14, 61-65, 2009
6. Yang, Y. J., Sheu, B. S., Chang, W. L., Cheng, H. C., & Yang, H. B. Increased Body Mass Index After H. pylori Eradication for Duodenal Ulcer Predisposes to Erosive Reflux Esophagitis. J Clin Gastroenterol, 2009
7. Cheng, H. C., Chang, W. L., Yeh, Y. C., Chen, W. Y., Tsai, Y. C., & Sheu, B. S. Seven-day intravenous low-dose omeprazole infusion reduces peptic ulcer rebleeding for patients with comorbidities. Gastrointest Endosc 70, 433-439, 2009
8. Chang, W. L., Sheu, B. S., Cheng, H. C., Yang, Y. J., Yang, H. B., & Wu, J. J. Resistance to metronidazole, clarithromycin and levofloxacin of Helicobacter pylori before and after clarithromycin-based therapy in Taiwan. J Gastroenterol Hepatol 24, 1230-1235, 2009
9. Yeh, Y. C., Cheng, H. C., Chang, W. L., Yang, H. B., & Sheu, B. S. Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females. BMC Microbiol 10, 218, 2010
10. Chuang, C. H., Hung, K. H., Chen, J. R., Chen, C. Y., Kao, A. W., Chang, W. L., Wu, J. J., & Sheu, B. S. Airway infection predisposes to peristomal infection after percutaneous endoscopic gastrostomy with high concordance between sputum and wound isolates. J Gastrointest Surg 14, 45-51, 2010
11. Chen, W. Y., Chang, W. L., Tsai, Y. C., Cheng, H. C., Lu, C. C., & Sheu, B. S. Double-dosed pantoprazole accelerates the sustained symptomatic response in overweight and obese patients with reflux esophagitis in Los Angeles grades A and B. Am J Gastroenterol 105, 1046-1052, 2010
12. Chang, W. L., Lin, F. C., Yen, C. J., Cheng, H., Lai, W. W., Yang, H. B., & Sheu, B. S. Esophageal lumen patency after concomitant chemoradiation therapy predict good survival in patients with esophageal squamous cell carcinoma. J Gastroenterol Hepatol 25, A60, 2010
13. Yeh, Y. C., Chang, W. L., Yang, H. B., Cheng, H. C., Wu, J. J., & Sheu, B. S. H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin alpha5beta1 related with gastric carcinogenesis. Mol Carcinog 50, 751-759, 2011
14. Chuang, C. H., Yang, H. B., Sheu, S. M., Hung, K. H., Wu, J. J., Cheng, H. C., Chang, W. L., & Sheu, B. S. Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer. BMC Microbiol 11, 121, 2011
15. Cheng, H. C., Yang, H. B., Chang, W. L., Yeh, Y. C., Tsai, Y. C., & Sheu, B. S. Weak up-regulation of serum response factor in gastric ulcers in patients with co-morbidities is associated with increased risk of recurrent bleeding. BMC Gastroenterol 11, 24, 2011
16. Cheng, H., Tsai, Y. C., Chen, W. Y., Chang, W. L., Cheng, H. C., & Sheu, B. S. Supplementation of Los Angeles classification with esophageal mucosa index of hemoglobin can predict the treatment response of erosive reflux esophagitis. Surg Endosc 25, 2478-2486, 2011
17. Chang, W. L., Yang, H. B., Cheng, H. C., Chuang, C. H., Lu, P. J., & Sheu, B. S. Increased gastric osteopontin expression by Helicobacter pylori infection can correlate with more severe gastric inflammation and intestinal metaplasia. Helicobacter 16, 217-224, 2011
18. Chang, W. L., Lin, F. C., Yen, C. J., Lai, W. W., Yang, H. B., & Sheu, B. S. Serum MMP-9 as a marker for detection and treatment response evaluation in patients with esophageal squamous cell carcinoma. Gastroenterol J Taiwan 28, 339-349, 2011
19. Chang, W. L., Lin, F. C., Yen, C. J., Cheng, H., Lai, W. W., Yang, H. B., & Sheu, B. S. Tumor length assessed by miniprobe endosonography can predict the survival of the advanced esophageal squamous cell carcinoma with stricture receiving concurrent chemoradiation. Dis Esophagus 24, 590-595, 2011
20. Chang, W. L., Kao, C. Y., Wu, C. T., Huang, A. H., Wu, J. J., Yang, H. B., Cheng, H. C., & Sheu, B. S. Gemifloxacin can partially overcome quinolone resistance of H. pylori with gyrA mutation in Taiwan. Helicobacter 17, 210-215, 2012
21. Kao, C. Y., Sheu, B. S., Sheu, S. M., Yang, H. B., Chang, W. L., Cheng, H. C., & Wu, J. J. Higher motility enhances bacterial density and inflammatory response in dyspeptic patients infected with Helicobacter pylori. Helicobacter 17, 411-416, 2012
22. Cheng, H. C., Yang, H. B., Chang, W. L., Chen, W. Y., Yeh, Y. C., & Sheu, B. S. Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers. ScientificWorldJournal 2012, 539316, 2012
23. Sheu, B. S., Cheng, H. C., Yeh, Y. C., & Chang, W. L. CYP2C19 genotypes determine the efficacy of on-demand therapy of pantoprazole for reflux esophagitis as Los-Angeles grades C and D. J Gastroenterol Hepatol 27, 104-109, 2012
24. Cheng, H. C., Chang, W. L., Chen, W. Y., Tsai, Y. C., Yeh, Y. C., & Sheu, B. S. Intravenous albumin shortens the duration of hospitalization for patients with hypoalbuminemia and bleeding peptic ulcers: a pilot study. Dig Dis Sci 58, 3232-3241, 2013
25. Sheu, B. S., Tsai, Y. C., Wu, C. T., Chang, W. L., Cheng, H. C., & Yang, H. B. Long-term celecoxib can prevent the progression of persistent gastric intestinal metaplasia After H. pylori eradication. Helicobacter 18, 117-123, 2013
26. Tsai, Y. C., Hsiao, W. H., Yang, H. B., Cheng, H. C., Chang, W. L., Lu, C. C., & Sheu, B. S. The corpus-predominant gastritis index may serve as an early marker of Helicobacter pylori-infected patients at risk of gastric cancer. Aliment Pharmacol Ther 37, 969-978, 2013
27. Wang, W. L., Chang, W. L., Yeh, Y. C., Lee, C. T., Chang, C. Y., Lin, J. T., & Sheu, B. S. Concomitantly elevated serum matrix metalloproteinases 3 and 9 can predict survival of synchronous squamous cell carcinoma of the upper aero-digestive tract. Mol Carcinog 52, 438-445, 2013
28. Yeh, Y. C., Cheng, H. C., Yang, H. B., Chang, W. L., & Sheu, B. S. H. pylori CagL-Y58/E59 prime higher integrin alpha5beta1 in adverse pH condition to enhance hypochlorhydria vicious cycle for gastric carcinogenesis. PLoS One 8, e72735, 2013
29. Cheng, H. C., Wu, C. T., Chang, W. L., Cheng, W. C., Chen, W. Y., & Sheu, B. S. Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study. Gut 63, 1864-1872, 2014
30. Kao, C. Y., Lee, A. Y., Huang, A. H., Song, P. Y., Yang, Y. J., Sheu, S. M., Chang, W. L., Sheu, B. S., & Wu, J. J. Heteroresistance of Helicobacter pylori from the same patient prior to antibiotic treatment. Infect Genet Evol 23, 196-202, 2014
31. Kuo, I. Y., Chang, J. M., Jiang, S. S., Chen, C. H., Chang, I. S., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W., & Wang, Y. C. Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients. Int J Med Sci 11, 779-787, 2014
32. Kuo, I. Y., Wu, C. C., Chang, J. M., Huang, Y. L., Lin, C. H., Yan, J. J., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W., & Wang, Y. C. Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression. Int J Cancer 135, 563-573, 2014
33. Chang, W. L., Wang, W. L., Chung, T. J., Lin, F. C., Yen, C. J., Lai, W. W., Yang, H. B., & Sheu, B. S. Response evaluation with endoscopic ultrasound and computed tomography in esophageal squamous cell carcinoma treated by definitive chemoradiotherapy. J Gastroenterol Hepatol 30, 463-469, 2015
34. Chang, W. L., Yang, H. B., Cheng, H. C., Yeh, Y. C., Kao, C. Y., Wu, J. J., Lu, C. C., & Sheu, B. S. Intracellular Osteopontin Induced by CagA-positive Helicobacter pylori Promotes Beta-catenin Accumulation and Interleukin-8 Secretion in Gastric Epithelial cells. Helicobacter, 2015